sp3dn-Orbital Hybrids and Molecular Geometry
نویسندگان
چکیده
منابع مشابه
Crystallographic and molecular-orbital studies on the geometry of antifolate drugs.
In the common dihydrofolate reductase inhibitors an amino substituent replaces the pteridine carbonyl oxygen atom of folates, with altered hydrogen-bonding properties and size. Flexibility in the amino groups could facilitate enzyme binding. Studies of cycloguanil hydrochloride by neutron diffraction show both in-plane and out-of-plane deformation of amino groups. Molecular-orbital calculations...
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ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 2004
ISSN: 0021-9584,1938-1328
DOI: 10.1021/ed081p1534